Differential expression of (dihydro)ceramide synthases in mouse brain: oligodendrocyte-specific expression of CerS2/Lass2

@article{Becker2007DifferentialEO,
  title={Differential expression of (dihydro)ceramide synthases in mouse brain: oligodendrocyte-specific expression of CerS2/Lass2},
  author={Ivonne Becker and Lihua Wang-Eckhardt and Afshin Yaghootfam and Volkmar Gieselmann and Matthias Eckhardt},
  journal={Histochemistry and Cell Biology},
  year={2007},
  volume={129},
  pages={233-241}
}
Synthesis of dihydroceramide is catalyzed by a family of (dihydro)ceramide synthases (CerS), first identified in yeast as longevity-assurance genes. Six members (CerS1–6; Lass1–6) of this gene family have been identified in mammals. We examined expression of CerS genes during postnatal development in mouse brain by means of Northern blot analysis, real-time RT-PCR, and in situ-hybridization. In situ-hybridization experiments showed that CerS1 was the predominant CerS in neurons throughout the… CONTINUE READING

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