Differential expression and regulation of Na(+)/H(+) exchanger isoforms in rabbit parietal and mucous cells.

@article{Rossmann2001DifferentialEA,
  title={Differential expression and regulation of Na(+)/H(+) exchanger isoforms in rabbit parietal and mucous cells.},
  author={Heidi Rossmann and T Sonnentag and Alexander Heinzmann and B. K. H. Seidler and Oliver P Bachmann and D. Vieillard-Baron and Michael Gregor and Ursula Seidler},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2001},
  volume={281 2},
  pages={G447-58}
}
Several Na(+)/H(+) exchanger (NHE) isoforms are expressed in the stomach, and NHE1 and NHE2 knockout mice display gastric mucosal atrophy. This study investigated the cellular distribution of the NHE isoforms NHE1, NHE2, NHE3, and NHE4 in rabbit gastric epithelial cells and their regulation by intracellular pH (pH(i)), hyperosmolarity, and an increase in cAMP. Semiquantitative RT-PCR and Northern blot experiments showed high NHE1 and NHE2 mRNA levels in mucous cells and high NHE4 mRNA levels in… CONTINUE READING

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2 Excerpts

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