Differential expression and regulation of IL-23 and IL-12 subunits and receptors in adult mouse microglia

@article{Li2003DifferentialEA,
  title={Differential expression and regulation of IL-23 and IL-12 subunits and receptors in adult mouse microglia},
  author={Jifen Li and Bruno Gran and Guang Xian Zhang and Elvira S. Ventura and Ines Siglienti and Abdolmohamad M. Rostami and Malek Kamoun},
  journal={Journal of the Neurological Sciences},
  year={2003},
  volume={215},
  pages={95-103}
}
IL-23 and IL-12 are functionally related heterodimeric cytokines that share the IL-12p40 subunit. IL-23 and IL-12 function through heterodimeric receptors, which share the IL-12Rbeta1 subunit. Production of IL-23, a heterodimer of IL-12p40 and IL-23p19, by CNS antigen-presenting cells (APC) is critical for susceptibility to experimental autoimmune encephalomyelitis (EAE), the animal model for multiple sclerosis (MS). We report that the expression of IL-23p19 mRNA is highly induced by… CONTINUE READING
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