Differential expression and regulation of microsomal prostaglandin E(2) synthase in human fetal membranes and placenta with infection and in cultured trophoblast cells.

@article{Premyslova2003DifferentialEA,
  title={Differential expression and regulation of microsomal prostaglandin E(2) synthase in human fetal membranes and placenta with infection and in cultured trophoblast cells.},
  author={Marina Premyslova and Wei Li and Nadia Alfaidy and Alan D. Bocking and Karen M. Campbell and William R Gibb and John R. G. Challis},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2003},
  volume={88 12},
  pages={6040-7}
}
We have evaluated the effect of chorioamnionitis on the protein expression of microsomal and cytosolic prostaglandin E(2) synthases (mPGES and cPGES) in preterm human placentae (PL) and fetal membranes (FM), by Western blot and immunohistochemistry, as well as the regulatory effect of IL-1beta and TNF-alpha on mPGES, cPGES, and cyclooxygenase (COX)-2 expression in villous trophoblast (VT) and chorion trophoblast (CT) cell cultures. mPGES localized to the syncytiotrophoblast and vascular… CONTINUE READING

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