Differential expression and phosphorylation of Pak1 and Pak2 in ovarian cancer: effects on prognosis and cell invasion.

@article{Siu2010DifferentialEA,
  title={Differential expression and phosphorylation of Pak1 and Pak2 in ovarian cancer: effects on prognosis and cell invasion.},
  author={Michelle K. Y. Siu and Esther S. Y. Wong and Hoi Yan Chan and Daniel S. H. Kong and Nina W S Woo and Kar Fai Tam and Hextan Yuen-Sheung Ngan and Queeny K Y Chan and Dominic Chun-Wan Chan and Kelvin Yuen-kwong Chan and Annie Nga-Yin Cheung},
  journal={International journal of cancer},
  year={2010},
  volume={127 1},
  pages={21-31}
}
Ovarian cancer is a gynecological malignancy with high mortality. Therefore, the identification of novel prognostic and therapeutic targets is important. p21-activated kinases (Paks) are involved in cytoskeleton reorganization. This study investigated the clinical significance of total and phosphorylated (p) Pak1 and Pak2 as well as their functional roles in ovarian cancer. Expressions of Pak1, p-Pak1 Thr(212), Pak2 and p-Pak2 Ser(20) in ovarian normal and cancerous cell lines as well as in… CONTINUE READING
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