Differential expression and pathological significance of autocrine motility factor/glucose‐6‐phosphate isomerase expression in human lung carcinomas

@article{Dobashi2006DifferentialEA,
  title={Differential expression and pathological significance of autocrine motility factor/glucose‐6‐phosphate isomerase expression in human lung carcinomas},
  author={Y. Dobashi and H. Watanabe and Y. Sato and S. Hirashima and T. Yanagawa and H. Matsubara and A. Ooi},
  journal={The Journal of Pathology},
  year={2006},
  volume={210}
}
To clarify the involvement of autocrine motility factor (AMF) in the phenotype and biological profiles of human lung carcinomas, we analysed protein and mRNA expression in a total of 180 cases. Immunohistochemistry revealed positive staining in 67.2%, with the highest frequency in squamous cell carcinoma (SCC; 90.8%) and the lowest in small cell carcinoma (SmCC; 27.8%). In SCC, the staining frequency and intensity correlated with the degree of morphological differentiation. Generally, the… Expand
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