Differential expression and pathological significance of autocrine motility factor/glucose‐6‐phosphate isomerase expression in human lung carcinomas

@article{Dobashi2006DifferentialEA,
  title={Differential expression and pathological significance of autocrine motility factor/glucose‐6‐phosphate isomerase expression in human lung carcinomas},
  author={Yoh Dobashi and Hayato Watanabe and Y Sato and Souichi Hirashima and Takashi Yanagawa and Hirochika Matsubara and Akishi Ooi},
  journal={The Journal of Pathology},
  year={2006},
  volume={210}
}
To clarify the involvement of autocrine motility factor (AMF) in the phenotype and biological profiles of human lung carcinomas, we analysed protein and mRNA expression in a total of 180 cases. Immunohistochemistry revealed positive staining in 67.2%, with the highest frequency in squamous cell carcinoma (SCC; 90.8%) and the lowest in small cell carcinoma (SmCC; 27.8%). In SCC, the staining frequency and intensity correlated with the degree of morphological differentiation. Generally, the… 
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References

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TLDR
AMF was observed in a wide spectrum of lesions of mesenchymal tissue, supporting the notion that it is involved in various cellular functions, including proliferation, differentiation, metabolism, and metastasis.
Expression of Autocrine Motility Factor Correlates with the Angiogenic Phenotype of and Poor Prognosis for Human Gastric Cancer
TLDR
The first clinical evidence that AMF expression is directly correlated with VEGF expression and MVD status and predicts clinical outcome in patients with gastric cancer is found, supporting the hypothesis that the AMF/AMF receptor pathway plays an important role in multiple aspects of cancer biology.
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TLDR
AMF and AMFR are overexpressed in human breast cancer and are negatively associated with patients' clinical outcome, which strongly indicates that the AMF–AMFR complex plays an important role in the progression of breast cancer, as well as having a prognostic role.
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TLDR
It is demonstrated that AMF is a poor prognostic factor in high‐grade astrocytomas.
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TLDR
Hypoxia may promote the metastatic potential of cancer cells through the enhanced autocrine motility factor/phosphohexase isomerase/neuroleukin mRNA expression and that the disruption of the hypoxia-inducible factor-1 pathway may be an effective treatment for metastasis.
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TLDR
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TLDR
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TLDR
It is concluded that the overexpression of AMF/PGI enhances cell proliferation together with up-regulation of cyclin/cyclin-dependent kinase activities and down- regulation of p27Kip1, whereas the induction of 3T3 fibroblast transformation by PGI is regulated by the retinoblastoma protein pathway.
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TLDR
It is established that AMF signaling induced anti‐apoptotic activity and that human fibrosarcoma HT‐1080 line that secreted high levels of AMF were resistant to drug‐induced apoptosis and might indicate a novel route by which tumor cells protect themselves with products, such as AMF, and proliferate despite various stresses and chemical insults.
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