Differential expression and interaction of host factors augment HIV-1 gene expression in neonatal mononuclear cells.

@article{Sundaravaradan2010DifferentialEA,
  title={Differential expression and interaction of host factors augment HIV-1 gene expression in neonatal mononuclear cells.},
  author={Vasudha Sundaravaradan and Roshni Mehta and David T. Harris and Jerome A. Zack and Nafees Ahmad},
  journal={Virology},
  year={2010},
  volume={400 1},
  pages={32-43}
}
We have previously shown a higher level of HIV-1 replication and gene expression in neonatal (cord) blood mononuclear cells (CBMC) compared with adult blood cells (PBMC), which could be due to differential expression of host factors. We performed the gene expression profile of CBMC and PBMC and found that 8013 genes were expressed at higher levels in CBMC than PBMC and 8028 genes in PBMC than CBMC, including 1181 and 1414 genes upregulated after HIV-1 infection in CBMC and PBMC, respectively… CONTINUE READING

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