Differential expression and functional characterization of luteinizing hormone receptor splice variants in human luteal cells: implications for luteolysis.

@article{Dickinson2009DifferentialEA,
  title={Differential expression and functional characterization of luteinizing hormone receptor splice variants in human luteal cells: implications for luteolysis.},
  author={Rachel Emma Dickinson and Anthony Stewart and Michelle D. Myers and Robert Peter Millar and William Colin Duncan},
  journal={Endocrinology},
  year={2009},
  volume={150 6},
  pages={
          2873-81
        }
}
The human LH receptor (LHR) plays a key role in luteal function and the establishment of pregnancy through its interaction with the gonadotropins LH and human chorionic gonadotropin. We previously identified four splice variants of the LHR in human luteinized granulosa cells (LGCs) and corpora lutea (CL). Real-time quantitative PCR revealed that expression of the full-length LHR (LHRa) and the most truncated form (LHRd) changed significantly in CL harvested at different stages of the ovarian… CONTINUE READING

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