Differential expression and DNA methylation of angiotensin type 1A receptors in vascular tissues during genetic hypertension development

@article{Pei2014DifferentialEA,
  title={Differential expression and DNA methylation of angiotensin type 1A receptors in vascular tissues during genetic hypertension development},
  author={Fang Pei and Xinquan Wang and Rongchuan Yue and Caiyu Chen and Ji Sheng Huang and Jie Huang and Xiaohui Li and Chunyu Zeng},
  journal={Molecular and Cellular Biochemistry},
  year={2014},
  volume={402},
  pages={1-8}
}
Angiotensin type 1a receptor (AT1aR) is thought to play an important role in the development of hypertension. However, it is unknown how the AT1aR expression in vascular tissue is changed during the development of hypertension or if the degree of methylation in the AT1aR promoter correlates with the expression of AT1aR. To address these questions, we measured AT1aR mRNA, protein expression, and methylation status of the AT1aR promoter in the aorta and mesenteric artery of male spontaneously… CONTINUE READING
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