Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.

@article{Shannon2003DifferentialEO,
  title={Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.},
  author={Mark Shannon and Aaron T. Hamilton and Laurie Gordon and Elbert Branscomb and Lisa Stubbs},
  journal={Genome research},
  year={2003},
  volume={13 6A},
  pages={1097-110}
}
Mammalian genomes carry hundreds of Krüppel-type zinc finger (ZNF) genes, most of which reside in familial clusters. ZNF genes encoding Krüppel-associated box (KRAB) motifs are especially prone to this type of tandem organization. Despite their prevalence, little is known about the functions or evolutionary histories of these clustered gene families. Here we describe a homologous pair of human and mouse KRAB-ZNF gene clusters containing 21 human and 10 mouse genes, respectively. Evolutionary… CONTINUE READING

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