Differential exocytosis from human endothelial cells evoked by high intracellular Ca(2+) concentration.

@article{Zupani2002DifferentialEF,
  title={Differential exocytosis from human endothelial cells evoked by high intracellular Ca(2+) concentration.},
  author={Gregor Zupan{\vc}i{\vc} and David Ogden and Christopher J. Magnus and Caroline P. D. Wheeler-Jones and Thomas D. Carter},
  journal={The Journal of physiology},
  year={2002},
  volume={544 3},
  pages={
          741-55
        }
}
Endothelial cells secrete a range of procoagulant, anticoagulant and inflammatory proteins by exocytosis to regulate blood clotting and local immune responses. The mechanisms regulating vesicular exocytosis were studied in human umbilical vein endothelial cells (HUVEC) with high-resolution membrane capacitance (C(m)) measurements. The total whole-cell C(m) and the amplitudes and times of discrete femtoFarad (fF)-sized C(m) steps due to exocytosis and endocytosis were monitored simultaneously… CONTINUE READING
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