Differential evolution of PSA-NCAM expression during aging of the rat telencephalon.

@article{Varea2009DifferentialEO,
  title={Differential evolution of PSA-NCAM expression during aging of the rat telencephalon.},
  author={Emilio Varea and Esther Castillo-G{\'o}mez and Mar{\'i}a {\'A}ngeles G{\'o}mez-Climent and Ramon Guirado and Jos{\'e} Miguel Blasco-Ib{\'a}ńez and Carlos Crespo and Francisco Jos{\'e} Mart{\'i}nez-Guijarro and Juan Nacher},
  journal={Neurobiology of aging},
  year={2009},
  volume={30 5},
  pages={808-18}
}
Changes in the ability of neuronal networks to undergo structural remodeling may be involved in the age-associated cognitive decline. The polysialylated form of the neural cell adhesion molecule (PSA-NCAM) declines dramatically during postnatal development, but persists in several regions of the young-adult rat telencephalon, where it participates, through its anti-adhesive properties, in neuronal structural plasticity. However, PSA-NCAM expression during aging has only been studied in the… CONTINUE READING