Differential equation modeling of HIV viral fitness experiments: model identification, model selection, and multimodel inference.

@article{Miao2009DifferentialEM,
  title={Differential equation modeling of HIV viral fitness experiments: model identification, model selection, and multimodel inference.},
  author={Hongyu Miao and Carrie Dykes and Lisa M. Demeter and Hulin Wu},
  journal={Biometrics},
  year={2009},
  volume={65 1},
  pages={292-300}
}
Many biological processes and systems can be described by a set of differential equation (DE) models. However, literature in statistical inference for DE models is very sparse. We propose statistical estimation, model selection, and multimodel averaging methods for HIV viral fitness experiments in vitro that can be described by a set of nonlinear ordinary differential equations (ODE). The parameter identifiability of the ODE models is also addressed. We apply the proposed methods and techniques… CONTINUE READING

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