Differential epitope positioning within the germline antibody paratope enhances promiscuity in the primary immune response.

@article{Sethi2006DifferentialEP,
  title={Differential epitope positioning within the germline antibody paratope enhances promiscuity in the primary immune response.},
  author={Dhruv K Sethi and Anupriya Agarwal and Venkatasamy Manivel and Kanury V. S. Rao and Dinakar M. Salunke},
  journal={Immunity},
  year={2006},
  volume={24 4},
  pages={429-38}
}
Correlation between the promiscuity of the primary antibody response and conformational flexibility in a germline antibody was addressed by using germline antibody 36-65. Crystallographic analyses of the 36-65 Fab with three independent dodecapeptides provided mechanistic insights into the generation of antibody diversity. While four antigen-free Fab molecules provided a quantitative description of the conformational repertoire of the antibody CDRs, three Fab molecules bound to structurally… CONTINUE READING

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