Differential electrophysiologic and inotropic effects of phenylephrine in atrial and ventricular heart muscle preparations from rats

@article{Ertl1991DifferentialEA,
  title={Differential electrophysiologic and inotropic effects of phenylephrine in atrial and ventricular heart muscle preparations from rats},
  author={Rudolf Ertl and Ulrich Jahnel and Hermann Nawrath and Edward E. Carmeliet and Johan S. Vereecke},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1991},
  volume={344},
  pages={574-581}
}
Stimulation of α1-adrenoceptors evokes a different pattern of inotropic responses in atrial and ventricular heart muscle preparations from rats. The inotropic effects are accompanied by different changes in membrane potential. In an attempt to clarify the question whether or to which extent these events are causally related, the effects of phenylephrine on force of contraction, transmembrane potential, Ca2+ current (ICa) and K+ currents were comparatively studied in either tissue. In atrial… CONTINUE READING