Differential effects on cellular iron metabolism of the physiologically relevant diatomic effector molecules, NO and CO, that bind iron.

@article{Watts2004DifferentialEO,
  title={Differential effects on cellular iron metabolism of the physiologically relevant diatomic effector molecules, NO and CO, that bind iron.},
  author={R. Watts and D. Richardson},
  journal={Biochimica et biophysica acta},
  year={2004},
  volume={1692 1},
  pages={
          1-15
        }
}
Both nitrogen monoxide (NO) and carbon monoxide (CO) are biologically relevant diatomic effector molecules that mediate a variety of biological functions through their avid binding to iron (Fe). Previous studies showed that NO can inhibit Fe uptake from transferrin (Tf) and increase Fe mobilisation from cells [J. Biol. Chem. 276 (2001) 4724]. We used CO gas, a CO-generating agent ([Ru(CO)3Cl2]2), and cells stably transfected with the CO-producing enzyme, haem oxygenase 1 (HO1), to assess the… Expand
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References

SHOWING 1-10 OF 47 REFERENCES
Examination of the mechanism of action of nitrogen monoxide on iron uptake from transferrin.
Nitrogen Monoxide (NO) and Glucose
...
1
2
3
4
5
...