Differential effects of ziprasidone and haloperidol on immobilization stress-induced mRNA BDNF expression in the hippocampus and neocortex of rats.

@article{Park2009DifferentialEO,
  title={Differential effects of ziprasidone and haloperidol on immobilization stress-induced mRNA BDNF expression in the hippocampus and neocortex of rats.},
  author={Sung Woo Park and Chan Hong Lee and Jung Goo Lee and Sun Jung Lee and Na Ri Kim and Sang Mi Choi and Young Hoon Kim},
  journal={Journal of psychiatric research},
  year={2009},
  volume={43 3},
  pages={274-81}
}
Recent in vivo and in vitro experiments have demonstrated that second-generation antipsychotic drugs (SGAs) might have neuroprotective effects. Ziprasidone is a SGA that is efficacious in the treatment of schizophrenia. In this study, we sought to analyze the effects of ziprasidone on the expression of the neuroprotective protein brain-derived neurotrophic factor (BDNF) in the rat hippocampus and neocortex, with or without immobilization stress. The effect of ziprasidone (2.5mg/kg) on the… CONTINUE READING