Differential effects of viral vectors on migratory afferent lymph dendritic cells in vitro predict enhanced immunogenicity in vivo.

@article{CubillosZapata2011DifferentialEO,
  title={Differential effects of viral vectors on migratory afferent lymph dendritic cells in vitro predict enhanced immunogenicity in vivo.},
  author={Carolina Cubillos-Zapata and E G{\'o}mez Guzm{\'a}n and Abigail H Turner and Sarah C Gilbert and Helen Prentice and Jayne C Hope and Bryan Charleston},
  journal={Journal of virology},
  year={2011},
  volume={85 18},
  pages={9385-94}
}
Targeting dendritic cells (DC) is key to driving effective immune responses. Lymphatic cannulation provides access to the heterogeneous populations of DC draining peripheral sites in rodents and ruminants. Afferent lymph DEC-205(+) CD11c(+) SIRPα(+) DC were preferentially infected ex vivo with three vaccine viral vectors: recombinant human replication-defective human adenovirus 5 (rhuAdV5), recombinant modified vaccinia virus Ankara (rMVA), and recombinant fowlpox virus (rFPV), all expressing… CONTINUE READING