Differential effects of viqualine on alcohol intake and other consummatory behaviors

  title={Differential effects of viqualine on alcohol intake and other consummatory behaviors},
  author={Claudio A. Naranjo and John T Sullivan and Karen E Kadlec and D Woodley-Remus and Gerry Kennedy and Edward Sellers},
  journal={Clinical Pharmacology \& Therapeutics},
Viqualine, a serotonin releaser and uptake inhibitor, was studied for its effects on consummatory behaviors (intake of ethanol and nonalcoholic beverages, cigarette smoking, and changes in body weight) in 29 men who were early‐stage problem drinkers between 21 to 55 years of age. Subjects were randomly assigned to receive a placebo and either 100 mg/day viqualine (n = 15) or 200 mg/day viqualine (n = 14) orally in a double‐blind crossover study. Viqualine administration and ethanol intake were… 
Fluoxetine differentially alters alcohol intake and other consummatory behaviors in problem drinkers
The findings with men who are problem drinkers indicate that fluoxetine differentially alters consummatory behaviors, and the reductions in alcohol intake and body weight are of clinical importance.
Enalapril effects on alcohol intake and other consummatory behaviors in alcoholics
It is indicated that enalapril does not alter alcohol intake in normotensive alcoholics with normal plasma renin activity and studies with higher doses of enAlapril in humans may be limited by increased frequency and severity of side effects.
Citalopram decreases desirability, liking, and consumption of alcohol in alcohol‐dependent drinkers
The findings indicate that serotonin uptake inhibitors may act by decreasing the urge to drink and the reinforcing effects of alcohol and a naturalistic outpatient trial is a sensitive, simple, and economic procedure for detecting these drug effects.
Effect of citalopram on alcohol intake in heavy drinkers.
Citalopram at the present dose appears capable of reducing alcohol intake only in a subgroup of heavy drinkers with a mean daily consumption of between 60 and 100 g pure alcohol.
Efficacy of dexfenfluramine in the treatment of alcohol dependence.
The results with dexfenfluramine are further evidence that serotonergic medications on their own do not significantly reduce alcohol consumption in alcohol-dependent individuals, and combination pharmacotherapy with agents that act on different receptors or neurotransmitter systems may be one way to enhanceSerotonergic effects on drinking behavior.
Effects of citalopram and a brief psycho-social intervention on alcohol intake, dependence and problems.
The short-term effects of C were replicated but no long-term effect was detected and Tolerance to citalopram, perhaps through some adaptive neurobiological changes, may have developed.
Evaluation of the Effects of Serotonin Uptake Inhibitors in Alcoholics: A Review
Patients with moderate dependence on alcohol showed a dose-dependent decrease in alcohol consumption, and SUI seem to have a differential effect on addictive behaviors since cigarette smoking did not decrease and consumption of nonalcoholic beverages was unaltered.
Ritanserin, a central 5-HT2 antagonist, in heavy social drinkers: desire to drink, alcohol intake and related effects.
The results indicate that ritanserin may have differential effects on alcohol intake, desire, craving and liking, intoxication and some of alcohol's effects on mood, and suggest that ritanerin has limited efficacy in reducing alcohol intake in heavy drinkers.
Effect of fluoxetine on alcohol consumption in male alcoholics.
The fluoxetine group had a 14% lower alcohol intake during the 1st week only, associated with a lower proportion of requests for alcohol and less craving for alcohol (as rated by research staff); there were no significant effects in later weeks.
Clinical efficacy of the 5-HT3 antagonist ondansetron in alcohol abuse and dependence.
Lower baseline drinking and higher level of education were significant and strong predictors of drinking reduction during treatment, and ondansetron was very well tolerated; hence, further long-term studies with 5-HT3 antagonists alone or in combination with other treatment components may offer promise for treatment of alcoholism.


Zimelidine‐induced variations in alcohol intake by nondepressed heavy drinkers
The data suggest that zimelidine modifies alcohol intake by a different mechanism than previously tested drugs, possibly by modulating the central neural mechanism that controls drinking of alcohol.
The serotonin uptake inhibitor citalopram attenuates ethanol intake
Citalopram, a selective serotonin uptake inhibitor, decreased the number of drinks consumed and increased the numbers of abstinent days in male nondepressed early‐stage problem drinkers and is probably through modulation of the neurobiologic mechanisms regulating ethanol intake.
Do serotonin uptake inhibitors decrease smoking? Observations in a group of heavy drinkers.
Zimelidine and citalopram effects on ethanol intake and smoking behavior were evaluated to exclude with 99.99% confidence the possibility that these drugs decrease smoking behavior by 50%.
Serotonin and Appetite
  • G. Curzon
  • Biology
    Annals of the New York Academy of Sciences
  • 1990
5-HT1A agonists (8-OHDPAT, buspirone, gepirone, etc.) stimulate intake in freely feeding rats, probably by activating autoreceptors on the cell bodies of 5- HT neurons so that 5-HT release at terminals is decreased and feeding in previously food-deprived rats is decreased.
The effect of PK5078, a new serotonin uptake inhibitor, on serotonin levels and uptake in human platelets, following administration to healthy volunteers.
A significant dose-related inhibition of 3H-serotonin uptake by platelets was observed following single oral doses of PK 5078, with maximal inhibition at 75 mg, and the rate of depletion of endogenous platelet serotonin was much slower with minimum levels being attained on the morning after the final dose.
Methods for evaluating addiction liability. (A) "Attitude" of opiate addicts toward opiate-like drugs. (B) a short-term "direct" addiction test.
A short, "double-blind," direct addiction, cross-over procedure of 18 to 20 days is satisfactory for developing significant degrees of physical dependence in the case of morphine and codeine-like drugs, but additional studies are necessary to determine its reliability for assessing the degree ofPhysical dependence induced by weak compounds and compounds in the methadone and meperidine series.
A New Depression Scale Designed to be Sensitive to Change
The construction of a depression rating scale designed to be particularly sensitive to treatment effects is described, and its capacity to differentiate between responders and non-responders to antidepressant treatment was better than the HRS, indicating greater sensitivity to change.
Purpose This self-report measure indicates the intensity of feelings of anxiety; it distinguishes between state anxiety (a temporary condition experienced in specific situations) and trait anxiety (a