Differential effects of vasopressin and norepinephrine on vascular reactivity in a long-term rodent model of sepsis.

@article{Barrett2007DifferentialEO,
  title={Differential effects of vasopressin and norepinephrine on vascular reactivity in a long-term rodent model of sepsis.},
  author={Lucinda K Barrett and Nelson N Orie and Valerie A. Taylor and Raymond P Stidwill and Lucie H Clapp and Mervyn Singer},
  journal={Critical care medicine},
  year={2007},
  volume={35 10},
  pages={2337-43}
}
OBJECTIVE There is escalating interest in the therapeutic use of vasopressin in septic shock. However, little attention has focused on mechanisms underlying its pressor hypersensitivity, which contrasts with the vascular hyporesponsiveness to catecholamines. We investigated whether a long-term rodent model of sepsis would produce changes in endogenous levels and pressor reactivity to exogenous norepinephrine and vasopressin comparable with those seen in septic patients. DESIGN In vivo and ex… CONTINUE READING

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