Differential effects of various Ca2+ antagonists.

  title={Differential effects of various Ca2+ antagonists.},
  author={Antonio J. Farr{\'e} and M A Colombo and Mar{\'i}a Fort and Bertha Guti{\'e}rrez},
  journal={General pharmacology},
  volume={22 1},
1. The effects of various Ca antagonists (nicardipine, nifedipine, verapamil, diltiazem, flunarizine, cinnarizine, lidoflazine and papaverine) were studied in one in vitro (inhibition of CaCl2 induced contractions in isolated rat aorta) and two in vivo tests [survival after BaCl2 in the rat and survival after arachidonic acid (AA) in the mouse]. 2. Test substances behave in different ways, thus suggesting varying mechanisms of action. 3. The three tests used are very simple and quick to perform… CONTINUE READING


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