Differential effects of vanadium, tungsten and molybdenum on inhibition of glucose formation in renal tubules and hepatocytes of control and diabetic rabbits: Beneficial action of melatonin and N-acetylcysteine

@article{Kiersztan2004DifferentialEO,
  title={Differential effects of vanadium, tungsten and molybdenum on inhibition of glucose formation in renal tubules and hepatocytes of control and diabetic rabbits: Beneficial action of melatonin and N-acetylcysteine},
  author={Anna Kiersztan and Katarzyna Winiarska and Jakub Drozak and M. Przedlacka and Michał Węgrzynowicz and Tomasz Frączyk and Jadwiga Bryla},
  journal={Molecular and Cellular Biochemistry},
  year={2004},
  volume={261},
  pages={9-21}
}
Effect of vanadyl acetylacetonate (VAc), tungstate and molybdate on gluconeogenesis has been studied in isolated hepatocytes and kidney-cortex tubules. In renal tubules of control and alloxan-diabetic animals, the rank order of the metal-compounds-induced (i) inhibition of glucose formation from alanine + glycerol + octanoate or aspartate + glycerol + octanoate, (ii) decrease in the mitochondrial membrane potential (ΔΨm), (iii) increase in the hydroxyl free radicals (HFR) generation and (iv… CONTINUE READING

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