Differential effects of uridine adenosine tetraphosphate on purinoceptors in the rat isolated perfused kidney.

Abstract

BACKGROUND AND PURPOSE Purinergic signalling plays an important role in vascular tone regulation in humans. We have identified uridine adenosine tetraphosphate (Up(4)A) as a novel and highly potent endothelial-derived contracting factor. Up(4)A induces strong vasoconstrictive effects in the renal vascular system mainly by P2X(1) receptor activation. However… (More)
DOI: 10.1111/j.1476-5381.2010.00914.x

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