Differential effects of trilostane and cyanoketone on the 3β-hydroxysteroid dehydrogenase-isomerase reactions in androgen and 16-androstene biosynthetic pathways in the pig testis

@article{Cooke1996DifferentialEO,
  title={Differential effects of trilostane and cyanoketone on the 3β-hydroxysteroid dehydrogenase-isomerase reactions in androgen and 16-androstene biosynthetic pathways in the pig testis},
  author={G. Cooke},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={1996},
  volume={58},
  pages={95-101}
}
  • G. Cooke
  • Published 1996
  • Biology, Medicine
  • The Journal of Steroid Biochemistry and Molecular Biology
  • 3 beta-Hydroxysteroid dehydrogenase-isomerase (3 beta-HSD-I) activity in the pig testis is responsible for the conversion of dehydroepiandrosterone (DHA) to 4-androstenedione and also for the conversion of 5,16-androstadien-3 beta-ol (andien-beta) to 4, 16-androstadien-3-one (dienone). Therefore, 3 beta-HSD-I plays an essential role in the biosynthesis of hormonally and pheromonally active steroids. Previous studies from this laboratory have suggested that the 3 beta-HSD-I reactions in the… CONTINUE READING
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