Differential effects of transforming growth factor-beta on the synthesis of extracellular matrix proteins by normal fetal rat calvarial bone cell populations

@article{Wrana1988DifferentialEO,
  title={Differential effects of transforming growth factor-beta on the synthesis of extracellular matrix proteins by normal fetal rat calvarial bone cell populations},
  author={Jeffrey L. Wrana and Masao Maeno and B Hawrylyshyn and Kaiwen Yao and C Domenicucci and Jaro Sodek},
  journal={The Journal of Cell Biology},
  year={1988},
  volume={106},
  pages={915 - 924}
}
To determine the effects of transforming growth factor-beta (TGF-beta) on the different cell types that exist in bone, cell populations (I-IV), progressively enriched in osteoblastic cells relative to fibroblastic cells, were prepared from fetal rat calvaria using timed collagenase digestions. TGF-beta did not induce anchorage-independent growth of these cells, nor was anchorage-dependent growth stimulated in most populations studied, despite a two- to threefold increase in the synthesis of… CONTINUE READING

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