Differential effects of the tricyclic antidepressant amoxapine on glycine uptake mediated by the recombinant GLYT1 and GLYT2 glycine transporters.

@article{Nez2000DifferentialEO,
  title={Differential effects of the tricyclic antidepressant amoxapine on glycine uptake mediated by the recombinant GLYT1 and GLYT2 glycine transporters.},
  author={Elena N{\'u}{\~n}ez and Beatriz L{\'o}pez-Corcuera and Jes{\'u}s Gonz{\'a}lez – V{\'a}zquez and Cecilio Gim{\'e}nez and Carmen Arag{\'o}n},
  journal={British journal of pharmacology},
  year={2000},
  volume={129 1},
  pages={200-6}
}
We examined the effects of nine different tricyclic antidepressant drugs on the glycine uptake mediated by the glycine transporter 1b (GLYT1b) and glycine transporter 2a (GLYT2a) stably expressed in human embryonic kidney 293 cells. Desipramine, imipramine, clomipramine, nomifensine and mianserin had no effect on the activity of the glycine transporters. Doxepin, amitriptyline and nortriptyline inhibited the two transporter subtypes to a similar extent. Amoxapine displayed a selective… CONTINUE READING

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