Differential effects of the selective D2-antagonist raclopride in the nucleus accumbens of the rat on spontaneous and d-amphetamine-induced activity

@article{Boss2004DifferentialEO,
  title={Differential effects of the selective D2-antagonist raclopride in the nucleus accumbens of the rat on spontaneous and d-amphetamine-induced activity},
  author={Ruud van den Boss and A. Cools and S. {\"O}gren},
  journal={Psychopharmacology},
  year={2004},
  volume={95},
  pages={447-451}
}
  • Ruud van den Boss, A. Cools, S. Ögren
  • Published 2004
  • Chemistry, Medicine
  • Psychopharmacology
  • The effect of the D2-antagonist raclopride was investigated in two test situations, which are presumed to involve dopamine (DA) transmission within the nucleus accumbens of the rat. Local injection of d-amphetamine sulphate (10 μg/0.5 μl) produced a marked increase in motor activity, measured as motility, locomotion, and rearing, which was dose- and time-dependently antagonised by local injection of raclopride (0.05–5.0 μg/0.5 μl). After an initial decrease, at low doses (0.05–0.25 μg/0.5 μl… CONTINUE READING
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