Differential effects of the peroxynitrite donor, SIN-1, on atrial and ventricular myocyte electrophysiology.


Oxidative stress has been implicated in the pathogenesis of heart failure and atrial fibrillation and can result in increased peroxynitrite production in the myocardium. Atrial and ventricular canine cardiac myocytes were superfused with 3-morpholinosydnonimine-N-ethylcarbamide (SIN-1), a peroxynitrite donor, to evaluate the acute electrophysiologic effects… (More)
DOI: 10.1097/FJC.0b013e31828748ca

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