Corpus ID: 19991901

Differential effects of the imidazole derivatives etomidate, ketoconazole and miconazole and of metyrapone on the secretion of cortisol and its precursors by human adrenocortical cells.

@article{Lamberts1987DifferentialEO,
  title={Differential effects of the imidazole derivatives etomidate, ketoconazole and miconazole and of metyrapone on the secretion of cortisol and its precursors by human adrenocortical cells.},
  author={S. Lamberts and E. Bons and H. Bruining and F. D. de Jong},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1987},
  volume={240 1},
  pages={
          259-64
        }
}

S. Lamberts, E. Bons, +1 author F. D. de Jong

Published 1987

Chemistry, Medicine

The Journal of pharmacology and experimental therapeutics

The direct effects of etomidate, ketoconazole, miconazole and metyrapone were investigated on the secretion of cortisol and its precursors by dispersed cells from the adrenal cortex of a normal individual and four patients with Cushing's syndrome. The drugs interfered with adrenocorticotropic hormone-stimulated cortisol secretion in a dose-dependent way. Desoxycortisol concentrations in the medium were increased after the addition of metyrapone and low doses of etomidate but were suppressed… CONTINUE READING

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