Corpus ID: 19991901

Differential effects of the imidazole derivatives etomidate, ketoconazole and miconazole and of metyrapone on the secretion of cortisol and its precursors by human adrenocortical cells.

@article{Lamberts1987DifferentialEO,
  title={Differential effects of the imidazole derivatives etomidate, ketoconazole and miconazole and of metyrapone on the secretion of cortisol and its precursors by human adrenocortical cells.},
  author={S. Lamberts and E. Bons and H. Bruining and F. D. de Jong},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1987},
  volume={240 1},
  pages={
          259-64
        }
}
  • S. Lamberts, E. Bons, +1 author F. D. de Jong
  • Published 1987
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • The direct effects of etomidate, ketoconazole, miconazole and metyrapone were investigated on the secretion of cortisol and its precursors by dispersed cells from the adrenal cortex of a normal individual and four patients with Cushing's syndrome. The drugs interfered with adrenocorticotropic hormone-stimulated cortisol secretion in a dose-dependent way. Desoxycortisol concentrations in the medium were increased after the addition of metyrapone and low doses of etomidate but were suppressed… CONTINUE READING
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