Differential effects of the calcium antagonist mibefradil in epicardial and intramyocardial coronary arteries.

@article{Kng1995DifferentialEO,
  title={Differential effects of the calcium antagonist mibefradil in epicardial and intramyocardial coronary arteries.},
  author={C F K{\"u}ng and Marcel R. Tschudi and Georg Noll and J P Clozel and Thomas Felix L{\"u}scher},
  journal={Journal of cardiovascular pharmacology},
  year={1995},
  volume={26 2},
  pages={312-8}
}
The efficacy of vasodilation depends on the drug and the contractile agonist involved. Furthermore, vasodilation also may be detrimental (i.e., coronary steal), possibly depending on the anatomic site and/or action of the vasodilator. We investigated the effects of Ca2+ antagonism in porcine epicardial and intramyocardial coronary arteries suspended in organ chambers filled with physiological salt solution (95% O2/5% CO2, 37 degrees C); isometric tension was measured. In epicardial vessels… CONTINUE READING
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