Differential effects of tenidap on the zymosan- and lipopolysaccharide-induced expression of mRNA for proinflammatory cytokines in macrophages.

@article{Bondeson1996DifferentialEO,
  title={Differential effects of tenidap on the zymosan- and lipopolysaccharide-induced expression of mRNA for proinflammatory cytokines in macrophages.},
  author={J. Bondeson and R. Sundler},
  journal={Biochemical pharmacology},
  year={1996},
  volume={52 1},
  pages={
          35-42
        }
}
  • J. Bondeson, R. Sundler
  • Published 1996
  • Biology, Medicine
  • Biochemical pharmacology
  • Tenidap is a novel antirheumatic drug that combines cyclooxygenase inhibition with cytokine modulating qualities. We demonstrate here that tenidap inhibits the zymosan-induced expression of both interleukin 1 and tumor necrosis factor alpha in macrophages, at the mRNA and protein levels. The concentration-dependence of the tenidap-induced inhibition of the expression of mRNA for these proinflammatory cytokines agrees with that of its inhibitory effects on zymosan-induced arachidonate… CONTINUE READING
    20 Citations
    Suppression of leukotriene B4 and tumour necrosis factor α release in acute inflammatory responses by novel prenylated hydroquinone derivatives
    • 24
    Dexamethasone Inhibits the Inducible Bioconversion of Glyceryl Trinitrate to Nitric Oxide
    • 1
    Modulation of acute and chronic inflammatory processes by cacospongionolide B, a novel inhibitor of human synovial phospholipase A2
    • 42
    • Highly Influenced

    References

    SHOWING 1-10 OF 26 REFERENCES
    Regulation of macrophage tumor necrosis factor production by prostaglandin E2.
    • 335
    • PDF