Differential effects of taxol on two human cancer cell lines.

Abstract

Taxol is the prototype of a new class of drugs with promise in the treatment of various cancers. Its mechanism of action is not fully understood. We have investigated the effects of taxol on two human cancer cell lines, HT-29, derived from a colon carcinoma, and SK-MEL-28, from a melanoma. Immunofluorescence staining for microtubules, cell cycle analysis by… (More)

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