Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells.

@article{Clarke2011DifferentialEO,
  title={Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells.},
  author={John D. Clarke and Anna H. E. Hsu and Zhen Yu and Roderick H Dashwood and Emily E. Ho},
  journal={Molecular nutrition & food research},
  year={2011},
  volume={55 7},
  pages={999-1009}
}
SCOPE Sulforaphane (SFN) is an isothiocyanate derived from cruciferous vegetables such as broccoli. The ability of SFN to inhibit histone deacetylase (HDAC) enzymes may be one mechanism by which it acts as a chemoprevention agent. The ability of a chemopreventive agent to specifically cause cytotoxicity in cancer and not normal cells is an important factor in determining its safety and clinical relevance. METHODS AND RESULTS We characterized the effects of SFN in normal (PrEC), benign… CONTINUE READING