Differential effects of steroids on the synthesis of polyunsaturated fatty acids by human neuroblastoma cells

@article{Extier2009DifferentialEO,
  title={Differential effects of steroids on the synthesis of polyunsaturated fatty acids by human neuroblastoma cells},
  author={Audrey Extier and M H Perruchot and Charlotte Baudry and Philippe Guesnet and Mm. P. Lavialle and J-P. Alessandri},
  journal={Neurochemistry International},
  year={2009},
  volume={55},
  pages={295-301}
}
Polyunsaturated fatty acids (PUFA) are crucial for proper functioning of cell membranes, particularly in brain. Biologically important PUFA include docosahexaenoic acid (n-3 series) and arachidonic acid (n-6 series) which can be formed from their respective dietary essential precursors, alpha-linolenic acid (ALA) and linoleic acid (LA). Steroid hormones are thought to modulate PUFA synthesis in humans but whether they regulate PUFA status in brain and/or in neural membranes is unknown. In human… CONTINUE READING
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