Differential effects of specific opioid receptor agonists on rat pup isolation calls.

  title={Differential effects of specific opioid receptor agonists on rat pup isolation calls.},
  author={Susan E. Carden and Gordon A. Barr and Myron A. Hofer},
  journal={Brain research. Developmental brain research},
  volume={62 1},
The possibility was investigated that specific opioid receptor types might selectively alter the production of isolation-induced ultrasonic vocalizations. Intracisternal injections of mu, delta and kappa opioid receptor agonists were administered to isolated 10-day-old rat pups. The mu receptor agonist [D-Ala2-NMe-Phe4-Gly-ol]-enkephalin (DAMGO) and delta receptor agonist [D-Pen2, D-Pen5]-enkephalin (DPDPE) both reduced the rate of isolation-induced ultrasonic calling in the absence of sedation… CONTINUE READING

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