Differential effects of somatostatin on adenylate cyclase as functional correlate for different brain somatostatin receptor subpopulations.

Abstract

In homogenates of rat hippocampus and striatum, but not substantia nigra, somatostatin (SRIF) inhibits forskolin-activated adenylate cyclase in nanomolar concentrations. However, SRIF can also stimulate adenylate cyclase in micromolar concentrations in homogenates of rat hippocampus and substantia nigra. The SRIF octapeptide SMS 201-995 solely inhibits the… (More)

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@article{Markstein1989DifferentialEO, title={Differential effects of somatostatin on adenylate cyclase as functional correlate for different brain somatostatin receptor subpopulations.}, author={Rudolf Markstein and Kurt A. Stoeckli and Jean Claude Reubi}, journal={Neuroscience letters}, year={1989}, volume={104 1-2}, pages={13-8} }