Differential effects of sodium butyrate and hyperosmolality on the modulation of alkaline phosphatases of LoVo cells.

@article{Herz1990DifferentialEO,
  title={Differential effects of sodium butyrate and hyperosmolality on the modulation of alkaline phosphatases of LoVo cells.},
  author={Fritz Herz and M Halwer},
  journal={Experimental cell research},
  year={1990},
  volume={188 1},
  pages={50-4}
}
LoVo cells produce term-placental and intestinal alkaline phosphatases. Hyperosmolality and sodium butyrate increase the levels of both, but the effect of sodium butyrate is more pronounced on the intestinal enzyme. When applied together, induction of term-placental alkaline phosphatase is additive and that of the intestinal enzyme is synergistic. Induction by either stimulus or by their mixture is independent of cell density. However, whereas the effect of hyperosmolality is readily reversible… CONTINUE READING