Differential effects of smoking and COPD upon circulating myeloid derived suppressor cells.

  title={Differential effects of smoking and COPD upon circulating myeloid derived suppressor cells.},
  author={Sergio Scrimini and J. Pons and A. Agusti and J. Soriano and B. Cosio and J. A. Torrecilla and B. N{\'u}{\~n}ez and R. C{\'o}rdova and A. Iglesias and A. Jahn and C. Crespi and J. Sauleda},
  journal={Respiratory medicine},
  volume={107 12},
  • Sergio Scrimini, J. Pons, +9 authors J. Sauleda
  • Published 2013
  • Medicine
  • Respiratory medicine
  • BACKGROUND Chronic obstructive pulmonary disease (COPD) is characterized by an enhanced and persistent innate and acquired immune response to tobacco smoking. Myeloid-derived suppressor cells (MDSCs) modulate T-cell responses by down-modulating the T cell receptor ζ chain (TCR ζ) through the catabolism of l-arginine. The effects of smoking on MDSCs and their potential participation in COPD immunopathogenesis have not been explored so far. METHODS To investigate it, we compared the level of… CONTINUE READING
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