Differential effects of single versus repeated alcohol withdrawal on the expression of endocannabinoid system-related genes in the rat amygdala.

@article{Serrano2012DifferentialEO,
  title={Differential effects of single versus repeated alcohol withdrawal on the expression of endocannabinoid system-related genes in the rat amygdala.},
  author={Antonia Serrano and Patricia Rivera and Francisco Javier Pav{\'o}n and Juan Manuel Decara and J. Gonz{\'a}lez Su{\'a}rez and Fernando Rodr{\'i}guez de Fonseca and Loren Howell Parsons},
  journal={Alcoholism, clinical and experimental research},
  year={2012},
  volume={36 6},
  pages={984-94}
}
BACKGROUND Endogenous cannabinoids such as anandamide and 2-arachidonoylglycerol (2-AG) exert important regulatory influences on neuronal signaling, participate in short- and long-term forms of neuroplasticity, and modulate stress responses and affective behavior in part through the modulation of neurotransmission in the amygdala. Alcohol consumption alters brain endocannabinoid levels, and alcohol dependence is associated with dysregulated amygdalar function, stress responsivity, and affective… CONTINUE READING
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