Differential effects of single versus multiple administrations of haloperidol and risperidone on functional outcome after experimental brain trauma.

@article{Kline2007DifferentialEO,
  title={Differential effects of single versus multiple administrations of haloperidol and risperidone on functional outcome after experimental brain trauma.},
  author={Anthony E. Kline and Jaime L Massucci and Roos D Zafonte and C. Edward Dixon and Judith R DeFeo and Emily H Rogers},
  journal={Critical care medicine},
  year={2007},
  volume={35 3},
  pages={919-24}
}
OBJECTIVES Antipsychotics are routinely administered to patients with traumatic brain injury, even though the benefits vs. risks of this approach on behavioral recovery are unclear. To clarify the issue, the present study evaluated the effect of single and multiple administrations of haloperidol and risperidone on functional outcome after traumatic brain injury. DESIGN Prospective and randomized study in rodents. SETTING Experimental research laboratory at the University of Pittsburgh… CONTINUE READING