Differential effects of short- and long-term bupivacaine treatment on α1-adrenoceptor-mediated contraction of isolated rat aorta rings and the reversal effect of lipid emulsion

  title={Differential effects of short- and long-term bupivacaine treatment on $\alpha$1-adrenoceptor-mediated contraction of isolated rat aorta rings and the reversal effect of lipid emulsion},
  author={Haochuan Guo and He-fei Zhang and Wen-qi Xu and Qian Du and Jing Zhao and Lei-ming Ren},
  booktitle={Acta Pharmacologica Sinica},
Aim:Arterial function is significantly influenced by bupivacaine at both clinically relevant concentrations and toxic concentrations, but the underlying mechanisms are not fully understood. In the present study we investigated the role of α1-adrenoceptors in bupivacaine effects on isolated rat aortas.Methods:Isolated aortic rings were prepared from rats and suspended in an organ bath. Phenylephrine (Phe)-induced vasoconstriction and acetylcholine (ACh)-induced vasodilation were recorded through… 

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