Differential effects of selective adenosine antagonists on the effort-related impairments induced by dopamine D1 and D2 antagonism.

@article{Nunes2010DifferentialEO,
  title={Differential effects of selective adenosine antagonists on the effort-related impairments induced by dopamine D1 and D2 antagonism.},
  author={Eric J. Nunes and Patrick Randall and Jessica L. Santerre and A B Given and Thomas Nicolaj Sager and Merc{\'e} Correa and John D Salamone},
  journal={Neuroscience},
  year={2010},
  volume={170 1},
  pages={268-80}
}
Mesolimbic dopamine (DA) is a critical component of the brain circuitry regulating behavioral activation and effort-related processes. Rats with impaired DA transmission reallocate their instrumental behavior away from food-reinforced tasks with high response requirements, and instead select less effortful food-seeking behaviors. Previous work showed that adenosine A(2A) antagonists can reverse the effects of DA D(2) antagonists on effort-related choice. However, less is known about the effects… CONTINUE READING