Differential effects of saturated and unsaturated fatty acid diets on cardiomyocyte apoptosis, adipose distribution, and serum leptin.

@article{Okere2006DifferentialEO,
  title={Differential effects of saturated and unsaturated fatty acid diets on cardiomyocyte apoptosis, adipose distribution, and serum leptin.},
  author={Isidore C. Okere and Margaret P. Chandler and Tracy A. McElfresh and Julie H Rennison and Victor G. Sharov and Hani N. Sabbah and K. -Y. Tserng and Brian D. Hoit and Paul R Ernsberger and Martin Elliot Young and William Stanley},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2006},
  volume={291 1},
  pages={H38-44}
}
Fatty acids are the primary fuel for the heart and are ligands for peroxisome proliferator-activated receptors (PPARs), which regulate the expression of genes encoding proteins involved in fatty acid metabolism. Saturated fatty acids, particularly palmitate, can be converted to the proapoptotic lipid intermediate ceramide. This study assessed cardiac function, expression of PPAR-regulated genes, and cardiomyocyte apoptosis in rats after 8 wk on either a low-fat diet [normal chow control (NC… CONTINUE READING

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