Differential effects of rosiglitazone on skeletal muscle and liver insulin resistance in A-ZIP/F-1 fatless mice.

@article{Kim2003DifferentialEO,
  title={Differential effects of rosiglitazone on skeletal muscle and liver insulin resistance in A-ZIP/F-1 fatless mice.},
  author={Jason Kim and Jonathan J. Fillmore and Oksana Gavrilova and Lily C Chao and Takamasa Higashimori and Hyejeong Choi and Hyo-Jeong Kim and Chunli Yu and Yan Chen and Xianqin Qu and Martin Haluz{\'i}k and Marc L Reitman and Gerald I Shulman},
  journal={Diabetes},
  year={2003},
  volume={52 6},
  pages={
          1311-8
        }
}
To determine the role of adipocytes and the tissue-specific nature in the insulin sensitizing action of rosiglitazone, we examined the effects of 3 weeks of rosiglitazone treatment on insulin signaling and action during hyperinsulinemic-euglycemic clamps in awake A-ZIP/F-1 (fatless), fat-transplanted fatless, and wild-type littermate mice. We found that 53 and 66% decreases in insulin-stimulated glucose uptake and insulin receptor substrate (IRS)-1-associated phosphatidylinositol (PI) 3-kinase… CONTINUE READING

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