Differential effects of retinoids and chronic ethanol consumption on membranes in rats.

@article{Kim1988DifferentialEO,
  title={Differential effects of retinoids and chronic ethanol consumption on membranes in rats.},
  author={C. I. Kim and Maria Anna Leo and N Lowe and Charles S. Lieber},
  journal={The Journal of nutrition},
  year={1988},
  volume={118 9},
  pages={
          1097-103
        }
}
Liver plasma membranes (LPM) were prepared from vitamin A-deficient and -sufficient rats as well as from animals treated with retinoic acid, with or without ethanol. Although the fluorescence polarization value of LPM prepared from retinoic acid-fed animals was significantly lower than that of controls (0.201 +/- 0.008 vs. 0.254 +/- 0.005, P less than 0.001), no effect was seen with a vitamin A-deficient diet (0.259 +/- 0.005). No change in the fluorescence polarization was observed in… 
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References

SHOWING 1-10 OF 39 REFERENCES
Effects of vitamin A and ethanol on liver plasma membrane fluidity
TLDR
It is concluded that liver plasma membranes contain a significant amount of vitamin A, that vitamin A supplementation increases membrane fluorescence polarization and that chronic ethanol administration can interfere with this effect.
Hepatic vitamin A depletion after chronic ethanol consumption in baboons and rats.
TLDR
It is concluded that chronic ethanol consumption decreases hepatic vitamin A, and that some mechanisms other than malnutrition and malabsorption may be involved in this process.
Effect of chronic ethanol administration on enzyme and lipid properties of liver plasma membranes in long and short sleep mice
TLDR
Chronic ethanol ingestion induces specific alterations in liver plasma membrane structure and function, suggesting that adaptive responses to ethanol may be determined in part by inherited factors.
Membrane effects of retinoids: possible correlation with toxicity.
Ethanol potentiates squamous metaplasia of the rat trachea caused by vitamin A deficiency.
TLDR
Ethanol consumption results in lysosomal and ciliary abnormalities in the ciliated cells of the tracheal epithelia that were not as yet involved in the formation of squamous metaplasia, which could contribute to the enhanced incidence of respiratory cancer seen in the alcoholic.
Increased vitamin A in esophagus and other extrahepatic tissues after chronic ethanol consumption in the rat.
TLDR
Significant increases of retinoids were also found in lungs, trachea, kidneys, and testes, but not in the eyes, which suggests that chronic ethanol consumption may be associated with some mobilization of vitamin A from the liver to other organs.
Plasma membrane changes of liver and Morris hepatoma induced by retinol in rats.
TLDR
It is indicated that the increased hepatic secretory activity after high doses of retinol leads to rapid turnover of incompletely fucosylated glycoproteins of the plasma membrane, which is related to malignant transformation and not to increased growth.
Chronic ethanol increases liver plasma membrane fluidity.
TLDR
The importance of ethanol metabolism in the observed plasma membrane changes was demonstrated in two ways: steady-state polarization of diphenylhexatriene (DPH), a probe of the hydrophobic core, and vesicles prepared from polar lipids alone, showed the same alterations in DPH polarization as did plasma membranes.
Subcellular localization of retinoids, retinoid-binding proteins, and acyl-CoA:retinol acyltransferase in rat liver.
Studies were conducted to define the subcellular localization of endogenous retinoids (vitamin A), retinoid-binding proteins, and acyl-CoA:retinol acyltransferase (ARAT) in liver and to determine
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