Differential effects of retinoic acid isomers on the expression of nuclear receptor co-regulators in neuroblastoma.

@article{Lovat1999DifferentialEO,
  title={Differential effects of retinoic acid isomers on the expression of nuclear receptor co-regulators in neuroblastoma.},
  author={Penny E. Lovat and Margherita Annicchiarico-Petruzzelli and Marco Corazzari and Martina Dobson and Archie J. Malcolm and Andrew D. J. Pearson and Gerry Melino and Christopher P. F. Redfern},
  journal={FEBS letters},
  year={1999},
  volume={445 2-3},
  pages={415-9}
}
Retinoic acid modulates growth and induces differentiation and apoptosis of neuroblastoma cells in vitro, with the all-trans and 9-cis isomers having different biological properties. Transcriptional activation in response to retinoic acid isomers is mediated by retinoic acid receptors and retinoid X receptors. The differential expression of co-activators and co-repressors which preferentially interact with retinoic acid receptors or retinoid X receptors may be a mechanism leading to different… CONTINUE READING

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