Differential effects of reactive oxygen species on native synovial fluid and purified human umbilical cord hyaluronate

@article{Saari2004DifferentialEO,
  title={Differential effects of reactive oxygen species on native synovial fluid and purified human umbilical cord hyaluronate},
  author={Herkko Saari and Yrj{\"o} T. Konttinen and Claes Friman and Timo Sorsa},
  journal={Inflammation},
  year={2004},
  volume={17},
  pages={403-415}
}
The ability of reactive oxygen species produced by triggered neutrophilic leukocytes, hypoxanthine/xanthine oxidase (HX/XAO), hydrogen peroxide, and hypochlorous acid/mycloperoxidase (HOC1/MPO) systems to degrade hyaluronate (HA) in human synovial fluid (SF) and purified umbilical cord HA was compared by measuring the molecular weight distribution of HA using high-performance liquid chromatography with a size-exclusion column. The exposure of noninflammatory SF to phorbol myristic acetate (PMA… Expand
Do stable nitroxide radicals catalyze or inhibit the degradation of hyaluronic acid?
TLDR
The results indicate that nitroxides protect hyaluronic acid from OH radicals generated enzymatically or radiolytically, and the protective effect is attributable neither to the scavenging of OH nor to the oxidation of reduced metal, but to the reaction of nitroxide with secondary carbohydrate radicals-most likely peroxyl radicals. Expand
Effects of hyaluronic acid on the polymorphonuclear leukocyte (PMN) release of active oxygen and protection of bovine corneal endothelial cells from activated PMNs.
TLDR
The results indicate that the action mechanism of HA proceeds not only through cell surface HA-receptor, but also acts as a physical barrier and/or a scavenger of superoxide. Expand
Glycosaminoglycan degradation by selected reactive oxygen species.
TLDR
This work focuses on the ROS-induced degradation of the glycosaminoglycans, one important component of the ECM, and investigates the mechanisms of the reactions of these ROS. Expand
Antioxidant properties of amniotic membrane: novel observations from a pilot study.
TLDR
Demonstrating total antioxidant capacity in AM provides evidence for use as a free radical scavenger and the antioxidant properties of AM and the contribution from HA require more research. Expand
Anti-oxidant inhibition of hyaluronan fragment-induced inflammatory gene expression
TLDR
The anti-oxidants NAC and DMSO, by inhibiting the HA induced inflammatory gene expression, may help re-balance excessive ROS induced inflammation. Expand
Biophysical Properties of Phenyl Succinic Acid Derivatised Hyaluronic Acid
TLDR
It is revealed that HA-PheSA is a strong quencher of electronic excited state PheSA and acts as a scavenger of singlet oxygen, thus medical applications of this derivatised form of HA may protect tissues and organs, such as skin, against reactive oxygen species damage. Expand
Effect of hyaluronic acid amide derivative on equine synovial fluid viscoelasticity.
TLDR
Results demonstrate that HY4 is able to integrate with SF, increasing the synovial fluid rheology, and could be an interesting new option in viscosupplement therapy of osteoarthritis, particularly considering its low degree of chemical modification from native HA. Expand
Ischemia-reperfusion does not cause significant hyaluronan depolymerization in skeletal muscle.
TLDR
Measurements following 24 h of reperfusion confirmed the absence of changes in the size or content of hyaluronan in tissue although an increased albumin content and wet weight-to-dry weight ratio indicated sustained edema. Expand
Comparative Effect of Nimesulide and Ibuprofen on the Urinary Levels of Collagen Type II C-Telopeptide Degradation Products and on the Serum Levels of Hyaluronan and Matrix Metalloproteinases-3 and -13 in Patients with Flare-Up of Osteoarthritis
TLDR
Patients with flare-up of their osteoarthritis disease process exhibit enhanced levels of markers of joint inflammation and cartilage collagen breakdown, which were markedly decreased by nimesulide but not by ibuprofen. Expand
Hyaluronic Acid ( HA ) Level in Ascitic Fluid of Cirrhotic Patients with Spontaneous Bacterial Peritonitis ( SBP )
Introduction: Spontaneous bacterial peritonitis (SBP) is a common problem that affects liver cirrhotic patients. It is also, a major contributor to the deterioration and aggravation of liver failureExpand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 34 REFERENCES
Reactive oxygen species and hyaluronate in serum and synovial fluid in arthritis.
TLDR
Results show that superoxide radical and hydroxyl radical may have different modes of action on SF HA, and the molecular-weight distribution of serum HA from patients with rheumatoid arthritis varied in different individuals and ranged between 275 X 10(3) and 650 X10(3). Expand
Oxygen derived free radicals and synovial fluid hyaluronate.
  • H. Saari
  • Medicine
  • Annals of the rheumatic diseases
  • 1991
TLDR
The results suggest that superoxide and hydroxyl radicals may have a different mode of action on synovial fluid hyaluronate. Expand
Changes in the viscosity of hyaluronic acid after exposure to a myeloperoxidase-derived oxidant.
TLDR
It is suggested that the reduction in viscosity of HA by the MPO/H2O2/CI- system may be due to a combination of oxidative cleavage and changes in the conformation of the molecule. Expand
Effect of oxygen-derived free radicals on hyaluronic acid.
TLDR
Generation of superoxide by leukocytes in vivo may account for the loss of synovial fluid viscosity that accompanies inflammatory joint disease. Expand
The generation of utilization of chlorinated oxidants by human neutrophils
Abstract The human neutrophil uses the hydrogen peroxide-myeloperoxidase-chloride system to generate a complex mixture of chlorinated oxidants which includes both hypochlorous acid (HOCI) and a wideExpand
Degradation of hyaluronic acid by polymorphonuclear leukocytes
TLDR
It is concluded that oxygen-derived free radicals are probably the major, if not sole, mechanism by which neutrophils might degrade hyaluronate. Expand
Chlorination of taurine by human neutrophils. Evidence for hypochlorous acid generation.
TLDR
It appears that stimulated human neutrophils can utilize the hydrogen peroxide-myeloperoxidase-chloride system to generate taurine chloramine, and the biologic reactivity and cytotoxic potential of hypochlorous acid and its chloramine derivatives suggest that these oxidants play an important role in the inflammatory response and host defense. Expand
Comparative aspects of oxidative metabolism of neutrophils from human blood and guinea pig peritonea: Magnitude of the respiratory burst, dependence upon stimulating agents, and localization of the oxidases
We have compared the subcellular sites of H2O2 and presumably also superoxide‐(O2−) production, and certain aspects of metabolic responses (O2 consumption, O2− production) of stimulated neutrophilsExpand
Stimulation of the hyaluronic acid levels of human synovial fibroblasts by recombinant human tumor necrosis factor α, tumor necrosis factor β (lymphotoxin), interleukin-1α, and interleukin-1β
TLDR
It is reported here that recombinant human tumor necrosis factor alpha, tumor Necrosis factor beta (lymphotoxin), interleukin-1 alpha, and interleuko-1 beta stimulate the hyaluronic acid (HA) levels of human synovial fibroblast-like cells. Expand
The particulate superoxide-forming system from human neutrophils. Properties of the system and further evidence supporting its participation in the respiratory burst.
TLDR
The evidence available suggests that this particulate O2- -forming system is the one responsible for the respiratory burst in activated neutrophils, and the relationship between this system and other O2--forming system found in human neutrophil is discussed. Expand
...
1
2
3
4
...