Differential effects of rapamycin on rods and cones during light-induced stress in albino mice.

@article{Kunchithapautham2011DifferentialEO,
  title={Differential effects of rapamycin on rods and cones during light-induced stress in albino mice.},
  author={Kannan Kunchithapautham and Beth Coughlin and John J. Lemasters and B{\"a}rbel Rohrer},
  journal={Investigative ophthalmology & visual science},
  year={2011},
  volume={52 6},
  pages={2967-75}
}
PURPOSE Autophagy is a lysosomal machinery-dependent process that catabolizes cellular components/organelles and proteins in an autophagic vacuole (AV)-dependent and -independent manner, respectively. Short-term exposure of the retina to bright light results in shortening of the outer segments, concomitant with AV formation. Autophagy is also induced by continuous long-term light damage, leading to photoreceptor cell death. Here the authors examined two questions: is autophagy induced during… CONTINUE READING
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