Differential effects of protein kinase C on the levels of epithelial Na+ channel subunit proteins.

@article{Stockand2000DifferentialEO,
  title={Differential effects of protein kinase C on the levels of epithelial Na+ channel subunit proteins.},
  author={James D Stockand and Hui Fang Bao and J. Schenck and Bela Malik and Patrick Middleton and Lynn E Schlanger and Douglas C. Eaton},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 33},
  pages={25760-5}
}
Regulation of epithelial Na(+) channel (ENaC) subunit levels by protein kinase C (PKC) was investigated in A6 cells. PKC activation altered ENaC subunit levels, differentially decreasing the levels of both beta and gamma, but not alphaENaC. Temporal regulation of beta and gammaENaC by PKC differed; gammaENaC decreased with a time constant of 3.7 +/- 1.0 h, whereas betaENaC decreased in 13.9 +/- 3. 0 h. Activation of PKC also resulted in a decrease in trans-epithelial Na(+) reabsorption for up… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 42 extracted citations

Similar Papers

Loading similar papers…