Differential effects of protein kinase C agonists on prostaglandin production and growth in human breast cancer cells

@article{Boorne2004DifferentialEO,
  title={Differential effects of protein kinase C agonists on prostaglandin production and growth in human breast cancer cells},
  author={A. J. Boorne and N. Donnelly and M. Schrey},
  journal={Breast Cancer Research and Treatment},
  year={2004},
  volume={48},
  pages={117-124}
}
A regulatory role for protein kinase C (PKC) and eicosanoids has been implicated in the control of breast cancer cell growth and function. Here we report on the effects of the two PKC agonists 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and bryostatin 1 on arachidonic acid metabolism, prostaglandin E2 (PGE2) production, and growth in MDA MB 231 human breast cancer cells. TPA caused a dose-dependent increase in PGE2 production which was maximal at 100 nM and which was blocked in the presence of… Expand
Comparison of stearidonic acid and alpha-linolenic acid on PGE2 production and COX-2 protein levels in MDA-MB-231 breast cancer cell cultures.
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CHAPTER 12 – BIOSYNTHETIC PRODUCTS FOR ANTICANCER DRUG DESIGN AND TREATMENT: THE BRYOSTATINS
TLDR
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